Description

Posatirelin is a synthetic tripeptide analog of thyrotropin-releasing hormone (TRH) with significant neuropharmacological activity. This compound is valued for its enhanced metabolic stability and potent central nervous system effects compared to the endogenous hormone. It is primarily utilized in advanced pharmaceutical research and development, serving as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies targeting neurological disorders.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of novel neuroprotective and nootropic drugs.
• Neuroscience Research: Used in preclinical studies to investigate mechanisms related to cognitive function, neuroprotection, and recovery from central nervous system injuries.
• Clinical Trials: Employed as the active component in formulations for clinical-stage research on conditions such as spinocerebellar degeneration and other neurodegenerative diseases.
• Biochemical Assays: Functions as a high-purity ligand and tool compound in receptor binding studies and pharmacological profiling assays.
• Peptide Synthesis: Acts as a sophisticated building block or target molecule for specialized peptide synthesis and process development.

Basic Information

Product Name	Posatirelin
CAS No.	78664-73-0
Molecular Formula	C16H22N6O4
Molecular Weight	362.39 g/mol
Synonyms	L-Pyroglutamyl-L-histidyl-L-prolinamide; (-)-L-Pyroglutamyl-L-histidyl-L-prolinamide; Pyroglutamyl-Histidyl-Proline amide; RGH-2202; TA-0910; CG-3703; Taltirelin Impurity; Thyrotropin-Releasing Hormone (TRH) Analog
EINECS	Contact for details

Quality Control

Our Posatirelin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral purity assessment, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the product should be handled in a low-humidity environment and desiccated for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.