Description

6-Ethynyl-Quinoline is a specialized organic building block featuring a quinoline core functionalized with a terminal ethynyl group. This unique molecular architecture, combining a nitrogen-containing heterocycle with a reactive alkyne moiety, makes it a valuable intermediate for advanced material science and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the fields of medicinal chemistry, organic electronics, and coordination chemistry for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targeting various disease pathways where the quinoline scaffold is pharmacologically active.
• Material Science Building Block: Used in the development of organic semiconductors, conductive polymers, and advanced organic frameworks (MOFs/COFs) due to its π-conjugated system and ability to participate in cross-coupling reactions.
• Ligand Synthesis: Acts as a starting material for creating sophisticated ligands used in catalysis and metal-organic chemistry, leveraging the coordinating ability of the nitrogen atom and the modifiable ethynyl group.
• Agrochemical Research: Employed in the discovery and development of new agrochemicals, where quinoline derivatives often exhibit herbicidal or fungicidal properties.
• Fluorescent Probe Development: Utilized in the design and synthesis of fluorescent markers and sensors for biological imaging and diagnostic applications.
• Academic & Industrial R&D: A crucial reagent for methodological studies in organic synthesis, including Sonogashira and other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	6-Ethynyl-Quinoline
CAS No.	78593-41-6
Molecular Formula	C11H7N
Molecular Weight	153.18 g/mol
Synonyms	6-Ethynylquinoline; Quinoline, 6-ethynyl-; 6-Ethynyl-1-azanaphthalene; 6-Ethynylquinoline (CAS 78593-41-6); 6-(Ethynyl)quinoline; 6-Quinolinylacetylene
EINECS	Contact for details

Quality Control

Our 6-Ethynyl-Quinoline is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for reliable and consistent supply to critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.