Description

o-tert-Butyl-D-Serine Methyl Ester Hydrochloride is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for introducing the D-serine moiety with a protected side chain, enabling precise control over stereochemistry in complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies in the development of peptide-based therapeutics, protease inhibitors, and other bioactive molecules where specific chirality and functional group protection are paramount.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for peptide drugs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate D-serine residues with a tert-butyl-protected side chain, crucial for modulating peptide stability and bioactivity.
• Protease Inhibitor Development: Serves as a building block for creating selective inhibitors targeting specific proteases, relevant in virology, oncology, and metabolic disease research.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and methodological research in synthetic organic chemistry.

Basic Information

Product Name	o-tert-Butyl-D-Serine Methyl Ester Hydrochloride
CAS No.	78537-14-1
Molecular Formula	C8H17NO3 • HCl
Molecular Weight	211.69 (Free base) / 248.14 (Hydrochloride salt)
Synonyms	D-Serine, O-(1,1-dimethylethyl)-, methyl ester, hydrochloride; Methyl (2R)-2-amino-3-[(2-methylpropan-2-yl)oxy]propanoate hydrochloride; (R)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride; D-O-tert-Butylserine methyl ester HCl; Methyl D-O-tert-butylserinate hydrochloride; (R)-2-Amino-3-(tert-butoxy)propionic acid methyl ester hydrochloride; D-Serine, O-tert-butyl-, methyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our o-tert-Butyl-D-Serine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.