Description

1-Pyrenyldiazomethane is a highly reactive and specialized diazo compound used as a derivatization reagent in analytical chemistry. Its core value lies in its ability to selectively and sensitively label target molecules, particularly carboxylic acids, for subsequent detection and quantification. This compound is essential for researchers and quality control laboratories in the pharmaceutical, environmental, and life science sectors who require advanced analytical methodologies for trace analysis.

Application

• Derivatization Agent for HPLC/LC-MS: Primarily used to label carboxylic acids, enhancing their UV absorption or fluorescence for highly sensitive detection in High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS).
• Fatty Acid Analysis: Employed in the analysis of short-chain and long-chain fatty acids in biological samples, food products, and industrial mixtures.
• Pharmaceutical Impurity Profiling: Facilitates the detection and quantification of carboxylic acid-containing impurities and degradation products in active pharmaceutical ingredients (APIs) and drug formulations.
• Environmental Monitoring: Used to derivatize acidic pollutants, such as phenolic compounds or herbicides, in water and soil samples for environmental analysis.
• Biomarker Research: Applied in metabolomics and proteomics research to tag and analyze carboxylic acid metabolites or post-translational modifications.
• Polymer Chemistry: Serves as a functionalization agent to introduce pyrene fluorophores onto polymer chains for photophysical studies.

Basic Information

Item	Detail
Product Name	1-Pyrenyldiazomethane
CAS No.	78377-23-8
Molecular Formula	C₁₇H₁₀N₂
Molecular Weight	242.28 g/mol
Synonyms	Pyrenyldiazomethane; 1-Diazoethylpyrene; 1-Pyrenyldiazomethane; (Pyren-1-yl)diazomethane; PDAM; Pyrene-1-diazomethane; 1-(Diazomethyl)pyrene
EINECS	Contact for details

Quality Control

Our 1-Pyrenyldiazomethane is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive and should be handled under subdued light. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Melting Point	Contact for details
Solubility	Soluble in common organic solvents (e.g., DCM, THF, Acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.