Description

(5R,6S)-5,6-Dihydrobenz[A]Anthracene-5,6-Diol CAS NO 78306-75-9 is a high-purity, stereospecific dihydrodiol derivative of benz[a]anthracene. This compound serves as a critical advanced synthetic intermediate and a valuable reference standard in research and development. It is primarily required by pharmaceutical R&D laboratories and academic research institutions focused on polycyclic aromatic hydrocarbon (PAH) metabolism, toxicology, and synthetic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex organic molecules and potential active pharmaceutical ingredients (APIs).
• Metabolite Reference Standard: Used as an analytical standard in studies of benz[a]anthracene metabolism, particularly for identifying and quantifying specific dihydrodiol metabolites.
• Biochemical Research: Employed in enzymatic studies, such as those involving epoxide hydrolase or cytochrome P450, to understand PAH activation and detoxification pathways.
• Toxicology and Carcinogenesis Studies: Serves as a precise tool for investigating the mechanisms of PAH-induced toxicity and DNA adduct formation.
• Organic Synthesis: Utilized in asymmetric synthesis and the development of novel chiral catalysts or ligands due to its defined stereochemistry.
• Analytical Method Development: Acts as a critical component for calibrating and validating HPLC, LC-MS, or GC-MS methods in environmental or biological monitoring.

Basic Information

Product Name	(5R,6S)-5,6-Dihydrobenz[A]Anthracene-5,6-Diol
CAS No.	78306-75-9
Molecular Formula	C18H14O2
Molecular Weight	262.30 g/mol
Synonyms	(5R,6S)-Benz[a]anthracene-5,6-dihydrodiol; (5R,6S)-BA-5,6-diol; (+)-(5R,6S)-Dihydroxy-5,6-dihydrobenz[a]anthracene; (5R,6S)-Dihydrobenzanthracene Diol; (5R,6S)-BA Dihydrodiol; (5R,6S)-5,6-Dihydroxy-5,6-dihydrobenz[a]anthracene; Stereoisomer of Benz[a]anthracene Dihydrodiol
EINECS	Contact for details

Quality Control

Our (5R,6S)-5,6-Dihydrobenz[A]Anthracene-5,6-Diol is manufactured under strict quality control protocols to ensure high chemical and stereochemical purity. Each batch is characterized using advanced analytical techniques, including chiral HPLC and NMR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing specific test results are provided and can be tailored to meet the requirements of research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.