Description

2-Chloroquinoline-6-Carbonitrile is a versatile and high-value heterocyclic building block, primarily utilized in advanced organic synthesis. Its core value proposition lies in its dual functionality, where the chloroquinoline scaffold and the nitrile group serve as key reactive sites for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, including kinase inhibitors, antiviral agents, and other biologically active quinoline derivatives.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides, leveraging the quinoline core for bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and other functional materials.
• Dye and Pigment Chemistry: Acts as an intermediate in the production of specialized quinoline-based dyes and colorants.
• Cross-Coupling Reactions: The chlorine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form carbon-carbon and carbon-heteroatom bonds.
• Nitrile Transformation Chemistry: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or used to form heterocycles like tetrazoles and amides.

Basic Information

Product Name	2-Chloroquinoline-6-Carbonitrile
CAS No.	78060-54-5
Molecular Formula	C10H5ClN2
Molecular Weight	188.61 g/mol
Synonyms	6-Cyano-2-chloroquinoline; 2-Chloro-6-cyanoquinoline; 2-Chloro-6-quinolinecarbonitrile; Quinoline, 2-chloro-6-cyano-; 2-Chlor-6-chinolincarbonitril (German); 2-クロロ-6-キノリンカルボニトリル (Japanese)
EINECS	Contact for details

Quality Control

Our 2-Chloroquinoline-6-Carbonitrile is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and mass spectrometry, for comprehensive identity confirmation and impurity profiling. A Certificate of Analysis (COA) detailing purity, assay, and specific test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.