Description

2,4-Dichloro-5-Methylquinazoline is a versatile and high-value halogenated quinazoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial importance lies in its role as a key building block for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals where the quinazoline scaffold is required.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various drug candidates, particularly kinase inhibitors and other biologically active molecules containing the quinazoline core.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and pesticides, leveraging its reactive chlorine sites for further functionalization.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for metal-organic frameworks (MOFs), and other specialty polymers.
• Chemical Biology & Proteomics: Serves as a scaffold for designing chemical probes and inhibitors to study enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-molecule libraries.

Basic Information

Product Name	2,4-Dichloro-5-Methylquinazoline
CAS No.	78052-20-7
Molecular Formula	C9H6Cl2N2
Molecular Weight	213.06 g/mol
Synonyms	5-Methyl-2,4-dichloroquinazoline; 2,4-Dichloro-5-methyl-quinazoline; Quinazoline, 2,4-dichloro-5-methyl-; 2,4-Dichloro-5-methylquinazoline; 78052-20-7 (CAS); 5-Methyl-2,4-dichloro-quinazoline
EINECS	Contact for details

Quality Control

Every batch of our 2,4-Dichloro-5-Methylquinazoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ISO standards for intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.