Description

(R)-4-Nitromandelic Acid is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its role in the synthesis of enantiomerically pure molecules, particularly in the development of active pharmaceutical ingredients (APIs). It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries where stereochemical control is critical.

Application

• Chiral Synthesis: A key intermediate in the asymmetric synthesis of complex organic molecules and APIs.
• Pharmaceutical Research: Used in the development and scale-up of novel drug candidates, especially those requiring the (R)-enantiomer configuration.
• Agrochemicals: Serves as a precursor for the synthesis of enantiopure herbicides and pesticides.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high stereoselectivity.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and catalysis.
• Ligand and Catalyst Preparation: Can be utilized to develop chiral ligands for asymmetric catalysis.

Basic Information

Product Name	(R)-4-Nitromandelic Acid
CAS No.	77977-73-2
Molecular Formula	C8H7NO5
Molecular Weight	197.14 g/mol
Synonyms	(R)-2-Hydroxy-2-(4-nitrophenyl)acetic acid; (R)-α-Hydroxy-4-nitrobenzeneacetic acid; (R)-4-Nitro-α-hydroxybenzenacetic acid; (R)-O2NC6H4CH(OH)COOH; D-4-Nitromandelic acid; (R)-(-)-4-Nitromandelic acid; (R)-Mandelic acid, 4-nitro-; (2R)-2-Hydroxy-2-(4-nitrophenyl)ethanoic acid
EINECS	Contact for details

Quality Control

Our (R)-4-Nitromandelic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.