Description

1,2-Cyclobutanediamine,3-Methyl-,(1-α-,2-α-,3-α-)-(9Ci) is a chiral, stereochemically defined diamine building block of significant interest in advanced organic synthesis. Its rigid cyclobutane core and strategically positioned amino groups make it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as chiral ligand synthesis, catalyst development, and the creation of novel active pharmaceutical ingredients (APIs).

Application

• Chiral Ligand and Catalyst Synthesis: Serves as a key scaffold for developing novel, enantioselective catalysts used in asymmetric hydrogenation, cross-coupling, and other stereocontrolled reactions.
• Pharmaceutical Intermediate: A critical building block in the synthesis of complex, biologically active molecules, particularly for creating chiral centers in drug candidates.
• Agrochemical Research: Used in the development of new pesticides and herbicides where specific stereochemistry is required for optimal activity and selectivity.
• Material Science Monomer: Potential precursor for specialty polymers, such as polyamides or polyimides, where the rigid, chiral structure can impart unique material properties.
• Chemical Biology Probe Development: Employed in the design of molecular probes and tools for studying enzyme mechanisms and biological pathways.
• Academic and Industrial R&D: A valuable reagent for methodological research in organic chemistry focused on ring-strain chemistry and stereoselective transformations.

Basic Information

Product Name	1,2-Cyclobutanediamine,3-Methyl-,(1-α-,2-α-,3-α-)-(9Ci)
CAS No.	77943-26-1
Molecular Formula	C5H12N2
Molecular Weight	100.16 g/mol
Synonyms	(1R,2R,3R)-3-Methylcyclobutane-1,2-diamine; (1R,2R,3R)-3-Methyl-1,2-cyclobutanediamine; (1α,2α,3α)-3-Methylcyclobutane-1,2-diamine; 3-Methyl-1,2-cyclobutanediamine (stereoisomer); cis-3-Methylcyclobutane-1,2-diamine; (1R,2R,3R)-1,2-Diamino-3-methylcyclobutane; 77943-26-1; 3-Methyl-cis-1,2-cyclobutanediamine
EINECS	Contact for details

Quality Control

Our production of 1,2-Cyclobutanediamine,3-Methyl-,(1-α-,2-α-,3-α-)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques, including chiral HPLC, GC, and NMR, to confirm identity, enantiomeric excess, and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.