Description

Ethyl 4-Chloro-6-Fluoroquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of novel quinolone and fluoroquinolone derivatives, which are a cornerstone class of broad-spectrum antibiotics. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active pharmaceutical ingredients (APIs) with enhanced efficacy.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing novel fluoroquinolone antibiotic candidates targeting resistant bacterial strains.
• Agrochemical Research: Used in the development of new crop protection agents and pesticides due to its bioactive quinoline core.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization to create libraries of compounds for high-throughput screening.
• Academic & Institutional R&D: Critical reagent for medicinal chemistry research focused on heterocyclic compounds and their biological activities.
• Fine Chemical Production: Employed in the manufacture of specialized, high-value chemicals for various industrial applications.

Basic Information

Product Name	Ethyl 4-Chloro-6-Fluoroquinoline-3-Carboxylate
CAS No.	77779-49-8
Molecular Formula	C₁₂H₉ClFNO₂
Molecular Weight	253.66 g/mol
Synonyms	4-Chloro-6-fluoroquinoline-3-carboxylic acid ethyl ester; Ethyl 4-chloro-6-fluoro-3-quinolinecarboxylate; 3-Quinolinecarboxylic acid, 4-chloro-6-fluoro-, ethyl ester; 77779-49-8; 4-Chloro-6-fluoroquinoline-3-carboxylate ethyl ester; Ethyl 4-chloro-6-fluoroquinoline-3-carboxylate; 4-Chloro-6-fluoro-3-quinolinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-6-Fluoroquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.