Description

Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Cis)- (9Ci) is a high-purity, chiral organofluorine building block of significant interest in advanced synthetic chemistry. Its unique cis-configured cyclopropane ring fused with a reactive acid chloride and a chlorofluoroalkene moiety makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where its stereochemistry and fluorine content are critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the cyclopropane and fluorine motifs contribute to enhanced efficacy and environmental stability.
• Material Science Research: Serves as a specialized monomer or cross-linking agent in the development of novel polymers with unique optical or electronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling or modifying biomolecules in probe development and bioconjugation strategies.
• Asymmetric Catalysis Ligand Precursor: Utilized in the synthesis of complex, chiral ligands for metal-catalyzed asymmetric transformations.
• Fluorine Chemistry Research: A valuable substrate for studying new fluorination reactions and the introduction of fluorinated functional groups into organic molecules.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Cis)- (9Ci)
CAS No.	77723-39-8
Molecular Formula	C8H9Cl2FO
Molecular Weight	211.06 g/mol
Synonyms	(1R,3S)-3-(2-Chloro-2-fluorovinyl)-2,2-dimethylcyclopropanecarbonyl chloride; (1R-cis)-3-(2-Chloro-2-fluoroethenyl)-2,2-dimethylcyclopropanecarboxylic acid chloride; 2,2-Dimethyl-3-(2-chloro-2-fluorovinyl)cyclopropanecarboxylic acid chloride, (1R,3S)-rel-; Cyclopropanecarboxylic acid, 3-(2-chloro-2-fluoroethenyl)-2,2-dimethyl-, (1R,3S)-, chloride; 3-(2-Chloro-2-fluoroethenyl)-2,2-dimethylcyclopropanecarbonyl chloride (cis-); (1R,3S)-3-(2-Chloro-2-fluorovinyl)-2,2-dimethyl-1-cyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, (1R-Cis)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for its application in sensitive synthetic pathways. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC-MS, and NMR spectroscopy. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and amines. Recommended storage temperature is 2-8°C for extended stability. The container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.