Description

Guanidine, 3-(Iodo-131I)Phenylmethyl- is a specialized radiopharmaceutical intermediate containing the iodine-131 radioisotope. This compound is critical for the synthesis of radiolabeled diagnostic and therapeutic agents, particularly in the field of nuclear medicine. It is primarily utilized by pharmaceutical R&D teams and radiochemistry manufacturers for developing targeted cancer therapies and advanced imaging probes.

Application

• Radiopharmaceutical Synthesis: Key precursor for labeling monoclonal antibodies, peptides, and small molecules with iodine-131 for targeted radiotherapy.
• Oncology Research: Development of novel theranostic agents for cancers such as thyroid carcinoma, neuroendocrine tumors, and lymphoma.
• Molecular Imaging Probe Development: Used in research to create SPECT (Single-Photon Emission Computed Tomography) imaging agents for disease localization and treatment monitoring.
• Preclinical & Clinical Studies: Serves as a critical material in both animal model studies and human clinical trials for evaluating new radiopharmaceuticals.
• API Manufacturing: Intermediate in the Good Manufacturing Practice (GMP) production of approved radioactive drugs.
• Bioconjugation Chemistry: Facilitates the attachment of radioactive iodine to biomolecules via its reactive guanidine and phenylmethyl groups.

Basic Information

Product Name	Guanidine, 3-(Iodo-131I)Phenylmethyl-
CAS No.	77679-27-7
Molecular Formula	C8H10131IN3
Molecular Weight	Contact for details
Synonyms	3-[(131I)Iodobenzyl]guanidine; MIBG (Iodine-131); Iobenguane (131I); I-131 MIBG; Meta-Iodobenzylguanidine, Iodine-131 Labeled; Adreview (brand name); Azedra (brand name); I-131 iobenguane sulfate
EINECS	Contact for details

Quality Control

This radiochemical is produced and controlled under a strict quality management system, adhering to current Good Manufacturing Practice (cGMP) principles where applicable. Each batch is tested to ensure critical parameters such as radiochemical purity, specific activity, and radiolabeling efficiency meet stringent specifications. A comprehensive Certificate of Analysis (COA) is provided, detailing analytical results from methods including HPLC and gamma spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. Due to the radioactive nature and specific decay properties of Iodine-131, storage, handling, and disposal must comply with all local and international regulations for radioactive materials. Shield appropriately.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC/Gamma)	Conforms
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Radionuclidic Purity (Gamma)	≥ 99.9%
pH	4.0 - 7.0
Sterility (where applicable)	Sterile
Bacterial Endotoxins (where applicable)	< 175 EU/Vial

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.