Description

Benzyl (3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. This compound is essential for research and development in medicinal chemistry, particularly for constructing complex molecules with specific stereochemistry. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially those targeting neurological and cardiovascular disorders.
• Asymmetric Synthesis: Used as a precursor or scaffold for constructing enantiomerically pure compounds in advanced organic synthesis.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and library development in drug discovery programs.
• Peptidomimetics: Employed in the design and synthesis of peptide analogs and mimetics due to its tetrahydroisoquinoline carboxylic acid structure.
• Catalyst and Ligand Development: Can be utilized as a precursor for developing novel chiral catalysts or ligands for asymmetric transformations.
• Reference Standard: Suitable for use as an analytical standard in quality control and method development for related pharmaceutical processes.

Basic Information

Product Name	Benzyl (3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride
CAS No.	77497-96-2
Molecular Formula	C17H18ClNO2
Molecular Weight	303.78 g/mol
Synonyms	(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid benzyl ester hydrochloride; Benzyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate hydrochloride; (S)-Benzyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate HCl; L-TIQ-OBzl hydrochloride; (S)-Benzyl tetrahydroisoquinoline-3-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Benzyl (3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.