Description

L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant chiral building block and synthetic intermediate. This compound is critical for the research and development of novel bioactive molecules, particularly in medicinal chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of drug candidates targeting neurological disorders, cardiovascular diseases, and oncology.
• Peptidomimetics Research: Used to incorporate constrained amino acid analogs into peptide chains to enhance stability and biological activity.
• Asymmetric Synthesis: Serves as a versatile starting material or chiral auxiliary in catalytic asymmetric transformations.
• Agrochemical Development: Building block for creating novel active ingredients with specific stereochemical requirements.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and receptor binding.
• Academic & Institutional R&D: Fundamental research reagent in universities and government labs for methodological development in organic synthesis.

Basic Information

Product Name	L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Hydrochloride
CAS No.	77497-95-1
Molecular Formula	C10H11NO2 · HCl
Molecular Weight	213.66 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid hydrochloride; L-Tic-OH · HCl; (3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride; L-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid hydrochloride; (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid monohydrochloride; L-TIQCA hydrochloride
EINECS	Contact for details

Quality Control

Our L-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.