Description

4-Carboxylic-Isatoic Anhydride is a versatile and reactive heterocyclic building block, primarily valued for its dual anhydride and carboxylic acid functionalities. This compound is essential for the synthesis of complex molecules, particularly in the development of advanced pharmaceutical intermediates and high-performance polymers. It is a critical raw material for research chemists and production specialists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of quinazoline and quinazolinone derivatives, which are core structures in various active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging its reactive sites for creating targeted bioactive molecules.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polyimides and polyamides with enhanced thermal and mechanical properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of complex organic colorants and fluorescent markers.
• Research & Development: A valuable tool in medicinal chemistry and material science for structure-activity relationship (SAR) studies and novel compound library generation.
• Peptide Mimetics: Utilized to construct constrained peptide analogs and other bioisosteres in drug discovery programs.

Basic Information

Product Name	4-Carboxylic-Isatoic Anhydride
CAS No.	77423-14-4
Molecular Formula	C9H5NO5
Molecular Weight	207.14 g/mol
Synonyms	4-Carboxyisatoic Anhydride; 1H-3,1-Benzoxazine-2,4(5H)-dione, 6-carboxy-; 6-Carboxy-1H-3,1-benzoxazine-2,4(5H)-dione; 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid; Isatoic Anhydride-4-carboxylic Acid; 4-CIA
EINECS	Contact for details

Quality Control

Our 4-Carboxylic-Isatoic Anhydride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed and under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.