Description

5-Fluoro-5'-o-Nitro-2'-Deoxyuridine is a chemically modified nucleoside analog, a key intermediate in the synthesis of more complex antiviral and anticancer agents. Its precise structure allows for targeted research into novel therapeutic mechanisms, particularly in the field of nucleoside-based prodrug development. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology and virology.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced nucleoside analogs for antiviral and anticancer drug discovery programs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA/RNA metabolism and repair pathways.
• Prodrug Development: Serves as a precursor for the design of prodrugs aimed at improving bioavailability and targeting specificity of therapeutic agents.
• Antiviral Agent Research: Investigated for its potential activity and mechanism against various viral families due to its fluorinated and nitro-modified structure.
• Oncology Research: Studied for its cytotoxic properties and potential to interfere with cancer cell proliferation as part of novel chemotherapeutic strategies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Fluoro-5'-o-Nitro-2'-Deoxyuridine
CAS No.	77421-85-3
Molecular Formula	C9H10FN3O7
Molecular Weight	291.19 g/mol
Synonyms	5-Fluoro-5'-nitro-2'-deoxyuridine; 5-Fluoro-5'-O-nitro-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-3-nitrotetrahydrofuran-2-yl]-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluoro-1-(2-deoxy-5-O-nitro-β-D-erythro-pentofuranosyl)uracil; 5-Fluoro-5'-nitro-dUrd; 5-Fluoro-5'-O-NO2-dUrd; 5-FN-dUrd; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 5-Fluoro-5'-o-Nitro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.