Description

1-[2-(2-Ethyl-6-Iodo-4-Oxo-Quinazolin-3-Yl)Ethyl]-3-Phenyl-1-Propan-2- Yl-Thiourea CAS NO 77301-17-8 is a sophisticated, high-purity quinazolinone derivative designed for advanced research and development. This compound is a critical intermediate in the synthesis of novel pharmaceutical agents, particularly those targeting specific enzymatic pathways. It is essential for medicinal chemistry researchers, process development scientists, and fine chemical manufacturers working in oncology, neurology, and other therapeutic areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the research and synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of new chemical entities.
• Biochemical Reagent: Serves as a reference standard or a probe compound in enzymatic and receptor binding assays within life science research.
• Process Development: Employed in scaling up synthetic routes for the cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.
• Custom Synthesis: Acts as a starting material for the contract manufacturing of specialized, high-value fine chemicals.

Basic Information

Product Name	1-[2-(2-Ethyl-6-Iodo-4-Oxo-Quinazolin-3-Yl)Ethyl]-3-Phenyl-1-Propan-2- Yl-Thiourea
CAS No.	77301-17-8
Molecular Formula	C22H23IN4OS
Molecular Weight	534.41 g/mol
Synonyms	1-[2-(2-Ethyl-6-iodo-4-oxo-3(4H)-quinazolinyl)ethyl]-3-phenyl-1-(1-methylethyl)-2-thiourea; 3-[2-[[(2-Phenyl-1-methylethyl)amino]thiocarbonylamino]ethyl]-2-ethyl-6-iodo-4(3H)-quinazolinone; N-[2-(2-Ethyl-6-iodo-4-oxo-3,4-dihydroquinazolin-3-yl)ethyl]-N'-(2-phenyl-1-methylethyl)thiourea; 77301-17-8; Quinazolinone thiourea derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.