Description

1-[2-(6-Bromo-2-Ethyl-4-Oxo-Quinazolin-3-Yl)Ethyl]-3-Phenyl-1-Propan-2-Yl-Thiourea is a high-purity, synthetically derived quinazolinone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chemical intermediate and a versatile pharmacological scaffold for designing novel therapeutic agents. It is primarily sought by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for its potential in creating targeted molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity in new chemical entities.
• Kinase Inhibitor Development: Investigated for the development of potential inhibitors due to the quinazolinone moiety's affinity for ATP-binding sites.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological processes and identify new therapeutic targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex heterocycles.
• Reference Standard: Serves as an analytical standard for quality control and method development in API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Item	Detail
Product Name	1-[2-(6-Bromo-2-Ethyl-4-Oxo-Quinazolin-3-Yl)Ethyl]-3-Phenyl-1-Propan-2-Yl-Thiourea
CAS No.	77301-15-6
Molecular Formula	C22H23BrN4OS
Molecular Weight	479.41 g/mol
Synonyms	1-[2-(6-Bromo-2-ethyl-4-oxoquinazolin-3-yl)ethyl]-3-phenyl-1-(propan-2-yl)thiourea; 3-[2-[[(2-Methylpropyl)amino]carbonothioylamino]ethyl]-6-bromo-2-ethyl-4(3H)-quinazolinone; 6-Bromo-2-ethyl-3-[2-[[(2-methylpropyl)amino]carbonothioylamino]ethyl]-4(3H)-quinazolinone; N-(2-Methylpropyl)-N'-[2-(6-bromo-2-ethyl-4-oxo-3-quinazolinyl)ethyl]thiourea; CAS 77301-15-6
EINECS	Contact for details

Quality Control

Our production of 1-[2-(6-Bromo-2-Ethyl-4-Oxo-Quinazolin-3-Yl)Ethyl]-3-Phenyl-1-Propan-2-Yl-Thiourea adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing all specifications, ensuring compliance with the exacting standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.