Description

2-[4-({[(2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Propanoyl]Oxy}Methyl)Phenyl]Acetic Acid is a high-purity, chiral organic compound featuring a protected amino acid moiety linked to a phenylacetic acid core. This molecular architecture makes it a critical building block in advanced pharmaceutical synthesis, particularly for the development of peptide-based therapeutics and prodrugs. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide drugs and targeted therapeutics.
• Prodrug Development: Used to create prodrug forms of active molecules, enhancing bioavailability and pharmacokinetic profiles.
• Bioconjugation: Serves as a linker molecule for attaching targeting ligands or payloads in antibody-drug conjugates (ADCs) and other bioconjugates.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides a stable, orthogonal protecting strategy for amines during multi-step syntheses.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing custom compounds for client projects.

Basic Information

Product Name	2-[4-({[(2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Propanoyl]Oxy}Methyl)Phenyl]Acetic Acid
CAS No.	77292-90-1
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	(S)-2-(4-((2-((tert-Butoxycarbonyl)amino)propanoyloxy)methyl)phenyl)acetic Acid; Boc-L-Ala-OCH2-Ph-CH2-COOH; N-Boc-L-Alanine 4-Carboxymethylbenzyl Ester; 4-[[[(2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxopropyl]oxy]methyl]benzenacetic Acid; N-(tert-Butoxycarbonyl)-L-alanine 4-(Carboxymethyl)benzyl Ester; BOC-L-Ala-OBzl(4-CH2COOH); L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(carboxymethyl)benzyl ester
EINECS	Contact for details

Quality Control

Our 2-[4-({[(2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Propanoyl]Oxy}Methyl)Phenyl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.