Description

tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-Methylbutyl]Carbamate is a high-purity, chiral building block of significant importance in advanced organic synthesis. This compound is specifically designed for the construction of complex molecules where precise stereochemistry and functional group compatibility are critical. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of peptide mimetics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other bioactive peptide derivatives.
• Peptidomimetics Research: Used in medicinal chemistry to create stable analogs of natural peptides with improved pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a building block for developing novel, chiral active ingredients for crop protection.
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke, multi-step synthetic routes.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines in complex multi-functional molecule assembly.
• Academic & R&D: A valuable reagent for methodological development in asymmetric synthesis and organocatalysis studies.

Basic Information

Product Name	tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-Methylbutyl]Carbamate
CAS No.	77284-59-4
Molecular Formula	C11H21N3O3
Molecular Weight	243.30 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanehydrazide; Boc-L-leucine hydrazide; tert-Butyl N-[(2S)-1-(hydrazinylcarbonyl)-3-methylbutyl]carbamate; (S)-tert-Butyl (1-(hydrazinecarbonyl)-3-methylbutyl)carbamate; Nα-Boc-L-leucine hydrazide; Boc-Leu-NHNH2; (2S)-2-[(tert-Butoxycarbonyl)amino]-4-methylpentanehydrazide
EINECS	Contact for details

Quality Control

Our production of tert-Butyl [(1S)-1-(Hydrazinocarbonyl)-3-Methylbutyl]Carbamate adheres to stringent quality management protocols. Every batch is characterized and tested to ensure high chiral purity and chemical integrity, meeting the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.