Description

(R)-α-[(Methylamino)Methyl]Spiro[Cyclopentane-1,1'-[1H]Indene]-3'-Methanol is a high-purity chiral intermediate featuring a unique spirocyclic indene structure. This compound is of significant value in pharmaceutical research and development, particularly for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including central nervous system (CNS) agents and other specialized drug candidates. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly in neurological and psychiatric drug research.
• Asymmetric Synthesis: Used in stereoselective chemical reactions to construct complex molecular architectures due to its defined (R)-configuration.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the efficient, scalable production of target drug molecules.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Chemical Biology Probes: Can be functionalized to create molecular probes for studying biological targets and pathways.

Basic Information

Product Name	(R)-α-[(Methylamino)Methyl]Spiro[Cyclopentane-1,1'-[1H]Indene]-3'-Methanol
CAS No.	77255-02-8
Molecular Formula	C17H23NO
Molecular Weight	257.37 g/mol
Synonyms	(R)-α-[(Methylamino)methyl]spiro[cyclopentane-1,1'-indene]-3'-methanol; (R)-3'-Hydroxymethyl-α-[(methylamino)methyl]spiro[cyclopentane-1,1'-indene]; (R)-Spiro[cyclopentane-1,1'-[1H]indene]-3'-methanol, α-[(methylamino)methyl]-; (R)-enantiomer of a spirocyclic amino alcohol intermediate.
EINECS	Contact for details

Quality Control

Our (R)-α-[(Methylamino)Methyl]Spiro[Cyclopentane-1,1'-[1H]Indene]-3'-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.