Description

2-Deoxy-D-Glucose-[1,2-3H(N)] is a radiolabeled analog of the glucose molecule, specifically tritiated at the 1 and 2 positions, making it an indispensable tool for metabolic research. This compound enables precise tracking and quantification of glucose uptake and glycolysis in biological systems, providing critical insights into cellular energy metabolism. It is primarily utilized by researchers and scientists in the fields of oncology, neurology, and metabolic disease studies, where understanding aberrant glucose metabolism is key.

Application

• Metabolic Pathway Tracing: Used as a tracer to study glucose uptake, hexokinase activity, and the glycolytic pathway in live cells and tissues.
• Cancer Research: Essential for investigating the Warburg effect, screening potential chemotherapeutic agents, and evaluating tumor metabolism in vitro and in vivo.
• Neurological Studies: Applied in research on brain energy metabolism, neuronal activity, and conditions like Alzheimer's disease and epilepsy.
• Drug Discovery & Development: Serves as a key reagent in high-throughput assays to identify compounds that modulate glucose metabolism.
• Diagnostic Agent Research: Supports the development of novel PET imaging agents by providing a radiolabeled precursor for analog synthesis.
• Microbiology: Used to study sugar transport and metabolism in bacteria, yeast, and other microorganisms.

Basic Information

Product Name	2-Deoxy-D-Glucose-[1,2-3H(N)]
CAS No.	77252-38-1
Molecular Formula	C6H113HO5
Molecular Weight	~165.1 g/mol (unlabeled); Specific activity varies.
Synonyms	2-Deoxy-D-[1,2-3H]Glucose; 2-DG-[1,2-3H]; D-[1,2-3H(N)]-2-Deoxyglucose; 2-Deoxy-3H-glucose; Radiolabeled 2-DG; Tritiated 2-Deoxyglucose; [1,2-3H]-2-Deoxy-D-glucose; 2-Fluoro-2-deoxy-D-glucose precursor (tritiated)
EINECS	Contact for details

Quality Control

Every batch of 2-Deoxy-D-Glucose-[1,2-3H(N)] is produced and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, solvent composition, and analytical methods (e.g., HPLC, radio-TLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. Users must handle this material in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity	≥ 95% (by HPLC or TLC)
Chemical Purity	≥ 98%
Solvent	Ethanol:Water (9:1) or as specified
Concentration	1 mCi/mL (Nominal)
Identification (HPLC)	Co-elutes with reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.