Description

123I-Mibg is a radiopharmaceutical diagnostic agent, specifically a meta-iodobenzylguanidine compound labeled with the iodine-123 radioisotope. This compound is critical for the non-invasive imaging and functional assessment of neuroendocrine tumors, such as neuroblastoma and pheochromocytoma. It is primarily utilized in nuclear medicine departments, research institutions, and pharmaceutical development facilities specializing in oncology and cardiology diagnostics.

Application

• Diagnostic Imaging for Neuroendocrine Tumors (NETs): Primary use in Single Photon Emission Computed Tomography (SPECT) for locating and staging tumors like pheochromocytoma, paraganglioma, and neuroblastoma.
• Cardiac Imaging: Used in myocardial sympathetic innervation imaging to assess conditions such as heart failure, arrhythmias, and diabetic cardiomyopathy.
• Oncology Research: Serves as a key tracer in preclinical and clinical research for studying tumor biology, receptor expression, and evaluating new therapeutic approaches.
• Pharmaceutical Development: Employed in the development and testing of new radiopharmaceuticals and targeted cancer therapies.
• Theragnostic Applications: Forms the diagnostic pair with its therapeutic counterpart (131I-MIBG) for patient selection and treatment monitoring in theranostic protocols.

Basic Information

Product Name	123I-Mibg
CAS No.	76924-93-1
Molecular Formula	C9H13123IN4
Molecular Weight	~ 360.13 g/mol (for 123I isotope)
Synonyms	Iobenguane I-123; I-123 MIBG; Meta-Iodobenzylguanidine I-123; Adreview (commercial name); 3-Iodobenzylguanidine-123I; 123I-Iobenguane; [123I]MIBG; MIBG Scan Tracer
EINECS	Contact for details

Quality Control

Every batch of 123I-Mibg is manufactured and released under strict radiopharmaceutical Good Manufacturing Practice (GMP) guidelines. Quality control includes rigorous testing for radiochemical purity (typically >95% by HPLC), radionuclidic purity, specific activity, pH, sterility, and apyrogenicity. A comprehensive Certificate of Analysis (COA) detailing all release specifications is provided with each shipment to ensure compliance with global pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the vial label. Due to the radioactive nature of Iodine-123 (half-life ~13.2 hours), shipments are scheduled to ensure optimal activity upon receipt. Follow all local and international regulations for the safe handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Retention time corresponds to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Radionuclidic Purity (Gamma Spectrometry)	≥ 99.9% I-123 at calibration time
Specific Activity	Contact for details
pH	4.5 - 7.5
Sterility Test (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< 175 EU/Vial

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.