Description

N1-Methyl-N1-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-1,3-Propanediamine is a high-purity, advanced pharmaceutical intermediate with a defined quinazoline-based structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting specific enzymatic pathways.
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities (NCEs) for various therapeutic areas.
• Kinase Inhibitor Development: Serves as a core structural component in the research of potential kinase inhibitors due to its quinazoline moiety.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Used in studies investigating protein-ligand interactions and biochemical assays.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and APIs.

Basic Information

Item	Details
Product Name	N1-Methyl-N1-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-1,3-Propanediamine
CAS No.	76362-29-3
Molecular Formula	C₁₄H₂₁N₅O₂
Molecular Weight	291.35 g/mol
Synonyms	1,3-Propanediamine, N1-methyl-N1-[4-amino-6,7-dimethoxy-2-quinazolinyl]-; N-Methyl-N-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine; 4-Amino-6,7-dimethoxy-2-[3-(methylamino)propylamino]quinazoline; PD 153035 Hydrochloride Intermediate; ZD 1839 Intermediate; Gefitinib Intermediate (precursor); Quinazoline derivative 76362-29-3
EINECS	Contact for details

Quality Control

Our N1-Methyl-N1-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-1,3-Propanediamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.