Description

n-Acetylneuraminic Acid Trimer Alpha(2-8) is a defined oligosaccharide composed of three sialic acid residues linked via alpha(2-8) glycosidic bonds. This high-purity reference standard is critical for advanced research and development in glycobiology and pharmaceutical sciences, enabling precise study of molecular interactions and biological pathways. It is an essential material for scientists and manufacturers in the biotechnology, diagnostic, and therapeutic sectors who require well-characterized, complex carbohydrates for their work.

Application

• Glycobiology Research: As a key reference standard for studying sialic acid polymers, gangliosides, and polysialic acid structures.
• Diagnostic Reagent Development: For the production of calibrators, controls, and antigens in immunoassays targeting bacterial meningitis pathogens like Neisseria meningitidis Group B.
• Vaccine Research & Development: In the design and evaluation of conjugate vaccines targeting polysialic acid capsules of pathogenic bacteria.
• Enzymatic Substrate: For studying the activity, kinetics, and inhibition of sialidases (neuraminidases) and sialyltransferases.
• Biopharmaceutical Characterization: Used in the analysis and quality control of therapeutic proteins, especially those with glycosylation patterns critical to function.
• Cell Biology & Neuroscience: Investigating the role of polysialic acid in cell adhesion, neural development, and synaptic plasticity.

Basic Information

Product Name	n-Acetylneuraminic Acid Trimer Alpha(2-8)
CAS No.	76152-09-5
Molecular Formula	C33H53N3O26
Molecular Weight	931.78 g/mol
Synonyms	Polysialic Acid Trimer (α2,8); Sialic Acid Trimer (α2-8); NANA Trimer (α2,8); Neu5Ac-α-(2→8)-Neu5Ac-α-(2→8)-Neu5Ac; Colominic Acid Trimer; Oligo-N-acetylneuraminic acid (α2,8); PolySia Trimer; α-2,8-Linked Sialic Acid Trimer
EINECS	Contact for details

Quality Control

Our n-Acetylneuraminic Acid Trimer Alpha(2-8) is produced under stringent quality management systems. Each batch is subjected to comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) with detailed batch-specific data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.