Description

4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block and pharmaceutical intermediate. This compound matters for its unique trifluoromethyl-substituted quinoline core, which imparts desirable properties like enhanced metabolic stability and lipophilicity in active molecules. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced material sectors for synthesizing novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in therapeutic areas targeting inflammation, oncology, and infectious diseases.
• Agrochemical Research: Used in the synthesis of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Fluorinated Compound Synthesis: Serves as a versatile precursor for creating complex fluorinated organic molecules in medicinal and material chemistry.
• Chemical Research & Development: Employed as a specialized building block in academic and industrial R&D for exploring new chemical entities and reaction pathways.
• Ligand and Catalyst Development: Potential use in designing novel chelating ligands or organocatalysts due to its carboxylic acid and heterocyclic nitrogen functionalities.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylic Acid
CAS No.	75999-60-9
Molecular Formula	C11H6F3NO3
Molecular Weight	257.17 g/mol
Synonyms	2-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid; 4-Hydroxy-2-trifluoromethyl-3-quinolinecarboxylic acid; 3-Quinolinecarboxylic acid, 4-hydroxy-2-(trifluoromethyl)-; 4-Hydroxy-2-(trifluoromethyl)quinoline-3-carboxylate; HQ3CA; TFMQCA
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.