Description

Ethyl 4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylate is a high-value, multifunctional quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring a trifluoromethyl group and ester functionality, makes it an essential building block for creating novel compounds with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in developing anti-infective, anti-inflammatory, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as light-emitting diodes (OLEDs) and charge-transport layers, due to its quinoline core.
• Fluorescent Probe Development: Utilized in the design and synthesis of fluorescent dyes and molecular probes for bioimaging and diagnostic applications.
• Academic & Contract Research: A valuable reagent for method development and discovery chemistry in university laboratories and contract research organizations (CROs).
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	Ethyl 4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylate
CAS No.	75999-59-6
Molecular Formula	C₁₃H₁₀F₃NO₃
Molecular Weight	285.22 g/mol
Synonyms	Ethyl 4-hydroxy-2-(trifluoromethyl)quinoline-3-carboxylate; 4-Hydroxy-2-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4-hydroxy-2-(trifluoromethyl)-, ethyl ester; 2-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid ethyl ester; Ethyl 2-trifluoromethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate; 75999-59-6; Quinoline-3-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our Ethyl 4-Hydroxy-2-(Trifluoromethyl)Quinoline-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This material should be stored separately from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.