Description

1,4-Dioxa-7-Azaspiro[4.4]Nonane-8-Carboxylicacid,(S)-(9Ci) is a high-purity, chiral spirocyclic building block of significant interest in advanced organic synthesis. Its unique constrained structure and defined stereochemistry make it a valuable intermediate for constructing complex molecular architectures with precise spatial orientation. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel, stereospecific pesticides and herbicides where the (S)-enantiomer imparts specific biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts.
• Peptidomimetics & Constrained Amino Acid Analogs: Incorporated into peptide backbones to enhance metabolic stability and conformational rigidity for biomedical research.
• Material Science Research: Explored as a monomer or cross-linker for developing specialty polymers with unique thermal and mechanical properties.
• Academic & Industrial R&D: A valuable tool for methodological studies in synthetic organic chemistry, particularly in spirocycle formation and stereoselective transformations.

Basic Information

Product Name	1,4-Dioxa-7-Azaspiro[4.4]Nonane-8-Carboxylicacid,(S)-(9Ci)
CAS No.	75776-51-1
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	(S)-1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid; (S)-8-Carboxy-1,4-dioxa-7-azaspiro[4.4]nonane; (S)-2-Oxazolidineacetic acid, α,α-tetramethylene-; (S)-Tetramethylene-2-oxazolidineacetic acid; L-Proline, 4,4-(tetramethylene)-5-oxo-, (S)-; (S)-Spirocyclic Proline Derivative; (S)-8-Carboxy-7-aza-1,4-dioxaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our 1,4-Dioxa-7-Azaspiro[4.4]Nonane-8-Carboxylicacid,(S)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profile is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.