Description

Dl-α-Methylleucine Methyl Ester Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of the non-proteinogenic amino acid α-methylleucine. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, enzyme inhibitors, and specialized peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological disorders.
• Peptidomimetic Synthesis: Used to incorporate non-natural, sterically hindered amino acid residues into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed as a tool compound in studies of protein structure-function relationships and enzyme mechanisms.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in stereoselective synthesis routes to create complex chiral molecules.
• Fine Chemical Production: An intermediate in the multi-step synthesis of specialized agrochemicals and other high-value organic compounds.

Basic Information

Product Name	Dl-α-Methylleucine Methyl Ester Hydrochloride
CAS No.	75691-29-1
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	DL-α-Methylleucine Methyl Ester Hydrochloride; Methyl 2-amino-4-methyl-2-pentanoate hydrochloride; 2-Amino-4-methyl-2-pentanoic acid methyl ester hydrochloride; α-Methyl-DL-leucine methyl ester HCl; DL-2-Amino-4-methyl-2-pentanoic acid methyl ester hydrochloride; Methyl α-methylleucinate hydrochloride; (RS)-α-Methylleucine methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Dl-α-Methylleucine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.