Description

R-3,3'-Bis(Phenyl)-1,1'-Bi-2-Naphthol is a high-value chiral ligand and catalyst precursor belonging to the BINOL derivative family. This compound is critically important for enabling highly selective asymmetric synthesis in advanced pharmaceutical and fine chemical manufacturing. It is primarily needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Zn, Al, Ti) in enantioselective reactions such as alkylations, aldol additions, and Diels-Alder cycloadditions.
• Pharmaceutical Intermediates: Key building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Chiral Resolution: Used in the preparation of chiral stationary phases for HPLC or as a resolving agent for racemic mixtures.
• Material Science Research: Serves as a monomer or precursor for chiral polymers and advanced organic materials with potential optical or electronic properties.
• Agrochemical Synthesis: Employed in the development of chiral pesticides and herbicides where specific stereochemistry is required for bioactivity and environmental safety.
• Academic & Industrial R&D: Fundamental tool in methodological development for new asymmetric transformations and process optimization.

Basic Information

Product Name	R-3,3'-Bis(Phenyl)-1,1'-Bi-2-Naphthol
CAS No.	75684-93-4
Molecular Formula	C32H22O2
Molecular Weight	438.52 g/mol
Synonyms	(R)-3,3'-Diphenyl-1,1'-bi-2-naphthol; (R)-3,3'-Diphenyl-BINOL; (R)-3,3'-Bis(phenyl)-[1,1'-binaphthalene]-2,2'-diol; R-Ph-BINOL; (R)-H8-BINOL derivative; (R)-3,3'-Diphenyl-2,2'-dihydroxy-1,1'-binaphthyl; R-3,3'-Diphenyl-1,1'-binaphthyl-2,2'-diol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity chiral chemicals. Every batch is characterized by chiral HPLC to confirm enantiomeric excess (typically >99%) and standard analytical techniques (NMR, IR, MS) for structural verification and purity assessment. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and specific rotation are available upon request. We adhere to cGMP principles where applicable for pharmaceutical-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent potential oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.