Description

2-Methylpropenoic Acid [[(3Ar,4R,6Z,10E,11Ar)-4-Acetoxy-2,3,3A,4,5,8,9,11A-Octahydro-10-Hydroxymethyl-3-Methylene-2-Oxocyclodeca[B]Furan-6-Yl]Methyl] Ester is a complex, high-value synthetic intermediate featuring a fused cyclodecane-furan ring system with multiple functional handles. This compound matters as a versatile chiral building block for the synthesis of structurally intricate molecules, offering significant value in advanced research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), especially in the areas of oncology, anti-infectives, and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates and novel therapeutic agents.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex natural products with fused polycyclic structures.
• Asymmetric Synthesis: Utilized in the development of new catalytic asymmetric reactions due to its multiple stereocenters and functional groups.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Advanced Material Science: Potential use as a monomer or cross-linker for creating specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	2-Methylpropenoic Acid [[(3Ar,4R,6Z,10E,11Ar)-4-Acetoxy-2,3,3A,4,5,8,9,11A-Octahydro-10-Hydroxymethyl-3-Methylene-2-Oxocyclodeca[B]Furan-6-Yl]Methyl] Ester
CAS No.	75683-56-6
Molecular Formula	C21H28O7
Molecular Weight	392.45 g/mol
Synonyms	Methacrylic Acid, [[(3Ar,4R,6Z,10E,11Ar)-4-Acetoxy-2,3,3A,4,5,8,9,11A-Octahydro-10-Hydroxymethyl-3-Methylene-2-Oxocyclodeca[B]Furan-6-Yl]Methyl] Ester; (3aR,4R,6Z,10E,11aR)-4-Acetoxy-6-[[(2-Methyl-1-oxo-2-propen-1-yl)oxy]methyl]-2,3,3a,4,5,8,9,11a-octahydro-10-(hydroxymethyl)-3-methylene-2-oxocyclodeca[b]furan; 2-Propenoic acid, 2-methyl-, [(3aR,4R,6Z,10E,11aR)-4-(acetyloxy)-2,3,3a,4,5,8,9,11a-octahydro-10-(hydroxymethyl)-3-methylene-2-oxocyclodeca[b]furan-6-yl]methyl ester; CAS 75683-56-6.
EINECS	Contact for details

Quality Control

Our 2-Methylpropenoic Acid [[(3Ar,4R,6Z,10E,11Ar)-4-Acetoxy-2,3,3A,4,5,8,9,11A-Octahydro-10-Hydroxymethyl-3-Methylene-2-Oxocyclodeca[B]Furan-6-Yl]Methyl] Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure identity, strength, and purity. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.