Description

Histamine Dihydrochloride R(-)-A-Methyl is a high-purity, stereochemically defined derivative of the biogenic amine histamine. This compound is a critical chiral building block and reference standard for advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and study of novel histamine receptor ligands, particularly for neurological and immunological applications.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of targeted H3 and H4 histamine receptor antagonists and agonists.
• Biochemical Research: Used as a high-affinity ligand in receptor binding assays and pharmacological studies to investigate histaminergic pathways.
• Reference Standard: Serves as an analytical standard for method development and quality control in the production of related active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Neuroscience Research: A tool compound for studying the role of histamine and its receptors in the central nervous system.

Basic Information

Product Name	Histamine Dihydrochloride R(-)-A-Methyl
CAS No.	75614-89-0
Molecular Formula	C6H13N3·2HCl
Molecular Weight	208.11 g/mol
Synonyms	(R)-(-)-α-Methylhistamine dihydrochloride; (R)-α-Methylhistamine 2HCl; (2R)-2-(1H-Imidazol-4-yl)propan-1-amine dihydrochloride; R(-)-α-Methylhistamine dihydrochloride; (R)-AMH dihydrochloride; HA-2HCl; R-(-)-AMH
EINECS	Contact for details

Quality Control

Every batch of Histamine Dihydrochloride R(-)-A-Methyl is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.