Description

(R)-(-)-α-Methylhistamine Dihydrobromide is a high-purity, enantiomerically pure derivative of histamine, specifically the (R)-(-) enantiomer, supplied as its stable dihydrobromide salt. This compound is a critical pharmacological reference standard and research chemical used extensively in the study of histamine H3 receptor activity and function. It is essential for researchers and manufacturers in pharmaceutical R&D, neuroscience, and medicinal chemistry who require a reliable and well-characterized ligand for receptor binding assays and the development of novel therapeutics.

Application

• Pharmacological Research: Primary use as a selective and potent agonist for histamine H3 receptors in vitro and in vivo studies.
• Neuroscience Studies: Investigation of neurotransmitter release modulation, sleep-wake cycles, and cognitive functions mediated by the central histaminergic system.
• Drug Discovery & Development: A key reference compound for screening and characterizing new H3 receptor-targeting drug candidates for conditions like narcolepsy, ADHD, and obesity.
• Biochemical Assay Standard: Used to calibrate and validate receptor binding assays (e.g., radioligand binding) and functional cellular assays.
• Academic Research: Fundamental research tool in university and institutional labs for studying G-protein coupled receptor (GPCR) signaling pathways.
• Chemical Intermediate: Potential use in the synthetic preparation of more complex molecules for medicinal chemistry programs.

Basic Information

Product Name	(R)-(-)-α-Methylhistamine Dihydrobromide
CAS No.	75614-87-8
Molecular Formula	C6H13N3 • 2HBr
Molecular Weight	322.02 g/mol
Synonyms	(R)-α-Methylhistamine Dihydrobromide; (R)-(-)-α-MeHA • 2HBr; (2R)-2-(1H-Imidazol-4-yl)-1-methyl-ethanamine Dihydrobromide; (R)-2-(1H-Imidazol-4-yl)propylamine Dihydrobromide; (R)-2-(4-Imidazolyl)propylamine Dihydrobromide; H3 Receptor Agonist (R)-Isomer; (R)-Methylhistamine Dihydrobromide; (R)-AMH Dihydrobromide
EINECS	Contact for details

Quality Control

Our (R)-(-)-α-Methylhistamine Dihydrobromide is manufactured under controlled conditions to ensure high enantiomeric purity and batch-to-batch consistency, suitable for advanced research applications. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess determination, NMR for structural confirmation, and stringent purity assays. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.