Description

(1S,9Ar)-Octahydro-2H-Quinolizin-1-Ylmethylamine Dihydrochloride is a high-purity, chiral organic salt primarily utilized as a sophisticated synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its defined stereochemistry and functional groups, which make it a critical building block for constructing complex molecules with specific biological activity. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents, particularly in areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for alkaloid-derived compounds and complex heterocycles.
• Medicinal Chemistry Research: Used in the discovery and optimization of new drug candidates, leveraging its quinolizidine scaffold for structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Chemical Reference Standard: Employed as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory synthetic projects and methodological studies.

Basic Information

Product Name	(1S,9Ar)-Octahydro-2H-Quinolizin-1-Ylmethylamine Dihydrochloride
CAS No.	75532-84-2
Molecular Formula	C11H22N2·2HCl
Molecular Weight	251.22 g/mol (Free base: 182.31 g/mol)
Synonyms	1-(Aminomethyl)octahydro-2H-quinolizine dihydrochloride; (1S,9aR)-Octahydro-2H-quinolizine-1-methanamine dihydrochloride; (1S,9aR)-1-(Aminomethyl)decahydroquinoline dihydrochloride; (1S,9aR)-1-Quinolizidinemethanamine dihydrochloride; (1S,9aR)-Octahydro-1-quinolizinylmethylamine dihydrochloride; (1S,9aR)-1-(Aminomethyl)quinolizidine dihydrochloride; Chiral quinolizidine amine dihydrochloride
EINECS	Contact for details

Quality Control

Our (1S,9Ar)-Octahydro-2H-Quinolizin-1-Ylmethylamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D applications. A detailed Certificate of Analysis (COA) providing specifications for chiral purity, assay, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.