Description

D-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key precursor for synthesizing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking reliable, high-quality intermediates for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used as a building block in the development of advanced pesticides and herbicides, leveraging its tetrahydroquinoline scaffold.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and dyes.
• Academic & Contract Research: A valuable reagent for medicinal chemistry research, process development, and scale-up studies in R&D laboratories.
• Peptidomimetics: The carboxylic acid functionality makes it a useful component in the design and synthesis of peptidomimetic compounds.

Basic Information

Product Name	D-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Hydrochloride
CAS No.	75433-76-0
Molecular Formula	C10H12NO2·HCl
Molecular Weight	213.67 g/mol
Synonyms	(2R)-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid hydrochloride; D-Tetrahydroquinoline-2-carboxylic acid HCl; (R)-1,2,3,4-Tetrahydro-2-quinolinecarboxylic acid hydrochloride; D-1,2,3,4-Tetrahydro-2-quinolinecarboxylic acid hydrochloride; (R)-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid hydrochloride; D-Tic-OH·HCl; (R)-Tic-OH·HCl
EINECS	Contact for details

Quality Control

Our D-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.