Description

6-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a saturated quinoline ring with a strategically positioned trifluoromethyl group, makes it a valuable intermediate for creating molecules with enhanced physicochemical properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a critical precursor for the development of novel active ingredients, where the CF3 group is instrumental in modulating bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research, where the trifluoromethyl group improves lipophilicity and metabolic resistance.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Material Science Precursor: Employed in the creation of specialty chemicals, including liquid crystals, organic semiconductors, and advanced polymers with unique electronic properties.
• Chemical Research & Development: Serves as a fundamental scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research focused on the synthesis and reactivity of organofluorine compounds.

Basic Information

Product Name	6-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	75414-00-5
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	6-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-6-(trifluoromethyl)quinoline; 6-Trifluoromethyl-1,2,3,4-tetrahydroquinoline; 6-(Trifluoromethyl)-3,4-dihydro-2H-quinoline; 6-Trifluoromethyltetrahydroquinoline; 6-CF3-Tetrahydroquinoline; 6-CF3-THQ; 75414-00-5
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation. A Certificate of Analysis (COA) detailing specific results for purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.