Description

R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol is a specialized chiral sulfonate ester derivative of 1,3-butanediol, serving as a valuable synthetic intermediate and protecting group reagent. Its primary value lies in its role as a key chiral building block for the stereoselective synthesis of complex organic molecules, particularly in pharmaceutical development. This compound is essential for researchers and manufacturers in the fine chemical, pharmaceutical, and agrochemical industries who require high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring specific stereochemistry.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in catalytic and stoichiometric asymmetric reactions to induce enantioselectivity.
• Protecting Group Chemistry: The tosylate (p-toluenesulfonate) group acts as a versatile protecting group for alcohols or as a good leaving group in nucleophilic substitution reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex natural products, flavors, fragrances, and advanced materials.
• Agrochemical Research: Serves as a building block for developing chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry laboratories and process chemistry research.

Basic Information

Product Name	R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol
CAS No.	75351-36-9
Molecular Formula	C11H16O4S
Molecular Weight	244.31 g/mol
Synonyms	(R)-1,3-Butanediol 1-(4-methylbenzenesulfonate); (R)-1-O-Tosyl-1,3-butanediol; (R)-1-Tosyloxy-1,3-butanediol; (R)-1,3-Butanediol 1-tosylate; (3R)-4-Hydroxy-2-methylbutyl 4-methylbenzenesulfonate; (R)-4-Hydroxy-2-methylbutyl tosylate; R-1-Tosyl-1,3-butanediol; (R)-1,3-Butanediol mono-p-toluenesulfonate
EINECS	Contact for details

Quality Control

Our R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis (HPLC, Chiral GC), identity confirmation (IR, NMR), and assay determination to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.