Description

1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-2-quinolinecarboxylic acid is a high-purity, advanced pharmaceutical intermediate belonging to the fluoroquinolone carboxylic acid class. This compound is a critical building block in the synthesis of modern antibacterial agents, offering significant value for research and commercial API manufacturing. It is primarily required by pharmaceutical R&D laboratories and fine chemical producers engaged in the development of next-generation antibiotic therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics, such as gemifloxacin and other structurally related compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold for constructing the quinolone nucleus in final API molecules.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new antibacterial agents.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Utilized in route scouting and optimization for scalable GMP manufacturing of fluoroquinolone drugs.

Basic Information

Product Name	1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-2-quinolinecarboxylic Acid
CAS No.	75338-42-0
Molecular Formula	C₁₂H₈F₃NO₃
Molecular Weight	271.19 g/mol
Synonyms	6,7,8-Trifluoro-1-ethyl-1,4-dihydro-4-oxoquinoline-2-carboxylic Acid; 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-2-carboxylic Acid; Gemifloxacin Intermediate; LB20304a; Factive Intermediate; 2-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6,7,8-trifluoro-4-oxo-; 75338-42-0
EINECS	Contact for details

Quality Control

Our 1-Ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-2-quinolinecarboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.