Description

4-Chloro-5-Nitroquinazoline is a versatile and high-value heterocyclic building block in organic synthesis. This compound is critical for the development of advanced pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily used by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors and other targeted cancer therapeutics.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, leveraging its bioactive quinazoline core.
• Chemical Biology Probe: Serves as a scaffold for creating tool compounds to study enzyme function and signal transduction pathways.
• Material Science Research: Investigated as a building block for organic electronic materials and photoactive compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific advanced intermediates.

Basic Information

Product Name	4-Chloro-5-Nitroquinazoline
CAS No.	75224-28-1
Molecular Formula	C8H4ClN3O2
Molecular Weight	209.59 g/mol
Synonyms	5-Nitro-4-chloroquinazoline; 4-Chloro-5-nitro-quinazoline; Quinazoline, 4-chloro-5-nitro-; 4-Chlor-5-nitrochinazolin (German); 4-クロロ-5-ニトロキナゾリン (Japanese); 4-Chloro-5-nitro-1,3-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Nitroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements of advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.