Description

trans-2-Fluorocyclohexanamine Hydrochloride is a high-purity chiral amine building block, essential for advanced pharmaceutical and agrochemical research and development. Its value lies in the unique stereochemistry and fluorine substitution, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and crop protection industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Peptidomimetics & Bioisosteres: The fluorine atom and amine functionality make it valuable for designing peptide mimics and bioisosteric replacements in medicinal chemistry.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science: Potential monomer or additive for specialty polymers and advanced materials requiring specific stereochemical or fluorinated properties.

Basic Information

Product Name	trans-2-Fluorocyclohexanamine Hydrochloride
CAS No.	75198-16-2
Molecular Formula	C6H13ClFN
Molecular Weight	153.63 g/mol
Synonyms	(1R,2R)-2-Fluorocyclohexanamine Hydrochloride; (1S,2S)-2-Fluorocyclohexanamine Hydrochloride; trans-2-Fluorocyclohexylamine Hydrochloride; rac-trans-2-Fluorocyclohexanamine HCl; 2-Fluorocyclohexanamine Hydrochloride (trans-); (±)-trans-2-Fluorocyclohexanamine Hydrochloride; 2-Fluoro-trans-cyclohexylamine Hydrochloride; FLUOROCYCLOHEXYLAMINE HYDROCHLORIDE (TRANS-)
EINECS	Contact for details

Quality Control

Our trans-2-Fluorocyclohexanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans- isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.