Description

(7R)-7,8,9,10-Tetrahydrobenzo[A]Pyrene-7β,8α,9β,10β-Tetrol CAS NO 75110-17-7 is a high-purity, stereochemically defined polycyclic aromatic hydrocarbon (PAH) metabolite. This compound is of significant value as a critical reference standard and biochemical research tool for studying metabolic pathways and DNA adduct formation. It is primarily sought by pharmaceutical R&D laboratories, analytical testing facilities, and academic research institutions engaged in toxicology and carcinogenesis studies.

Application

• Analytical Reference Standard: Used as a primary standard in HPLC, LC-MS, and GC-MS for the quantification of benzo[a]pyrene metabolites in environmental and biological samples.
• Biochemical Research: Serves as a key intermediate in studies investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs) and their genotoxic effects.
• Toxicology Studies: Employed in in vitro and in vivo research to understand DNA adduct formation, mutagenicity, and the mechanisms of PAH-induced carcinogenesis.
• Method Development & Validation: Essential for developing and validating sensitive analytical methods in regulatory, forensic, and environmental testing laboratories.
• Pharmaceutical Impurity Profiling: Used in the identification and characterization of potential genotoxic impurities in active pharmaceutical ingredients (APIs).
• Educational & Academic Use: Provides a defined compound for teaching advanced concepts in organic chemistry, toxicology, and environmental science.

Basic Information

Product Name	(7R)-7,8,9,10-Tetrahydrobenzo[A]Pyrene-7β,8α,9β,10β-Tetrol
CAS No.	75110-17-7
Molecular Formula	C₂₀H₁₆O₄
Molecular Weight	320.34 g/mol
Synonyms	(+)-7,8,9,10-Tetrahydrobenzo[a]pyrene-7,8,9,10-tetrol; (7R,8S,9S,10R)-7,8,9,10-Tetrahydrobenzo[a]pyrene-7,8,9,10-tetrol; Benzo[a]pyrene-7,8,9,10-tetrahydrotetrol; BP-7,8,9,10-tetrol; B[a]P-tetrol; anti-BPDE Hydrolysis Product; Benzo[a]pyrene Diol Epoxide Hydrolysis Product; 7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene
EINECS	Contact for details

Quality Control

Every batch of our (7R)-7,8,9,10-Tetrahydrobenzo[A]Pyrene-7β,8α,9β,10β-Tetrol is manufactured and analyzed under strict quality management systems. We guarantee high chemical and stereochemical purity, verified by advanced chromatographic and spectroscopic techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.