Description

1-O,5-O:2-O,3-o-Bis(Ethylboranediyl)-β-D-Ribofuranose CAS NO 74779-73-0 is a specialized organoboron derivative of ribofuranose, a key sugar moiety. This compound is of significant interest as a protected intermediate in the synthesis of complex nucleoside analogs and carbohydrate-based pharmaceuticals. It is primarily required by research institutions and pharmaceutical development teams working on antiviral agents, modified oligonucleotides, and novel boron neutron capture therapy (BNCT) candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Boron Neutron Capture Therapy (BNCT) Research: Serves as a precursor for developing sugar-conjugated boron delivery agents for targeted cancer therapies.
• Carbohydrate Chemistry: Used in academic and industrial research for studying protected sugar chemistry and creating complex oligosaccharide mimics.
• Oligonucleotide Synthesis: Acts as a modified ribose component for introducing boron functionalities into synthetic RNA strands for structural and therapeutic studies.
• Chemical Biology Probes: Enables the creation of labeled sugar molecules for investigating metabolic pathways and glycosylation processes.
• Process Development: Employed in scaling up routes to boron-containing active pharmaceutical ingredients (APIs) under GMP-like conditions.

Basic Information

Product Name	1-O,5-O:2-O,3-o-Bis(Ethylboranediyl)-β-D-Ribofuranose
CAS No.	74779-73-0
Molecular Formula	C9H16B2O5
Molecular Weight	233.84 g/mol
Synonyms	1,5:2,3-Bis-O-(ethylboranediyl)-β-D-ribofuranose; Ethylboronate Ribofuranose Derivative; D-Ribofuranose, 1,5:2,3-bis-O-(ethylboranediyl)-, β-; 1,2:3,5-Di-O-ethylboranyl-β-D-ribofuranose; Ribofuranose Bis(ethylboronate); CAS 74779-73-0; Protected Ribofuranose Boronate Ester
EINECS	Contact for details

Quality Control

Our high-purity organoboron intermediates are produced under strict quality systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) when opening the primary container to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.