Description

Methyl-Peg3-Ms CAS NO 74654-05-0 is a specialized polyethylene glycol (PEG)-based linker and chemical building block featuring a terminal methanesulfonate (mesylate) group. This bifunctional compound is critical for introducing short, hydrophilic PEG spacers and enabling subsequent nucleophilic substitution reactions in synthetic chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical, bioconjugation, and advanced materials sectors for constructing complex molecules, modifying surfaces, and developing targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key reagent in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or nanoparticles via its reactive mesylate group.
• Polymer Chemistry: Acts as a functional initiator or monomer for creating PEGylated polymers with controlled architectures.
• Surface Modification: Employed to graft hydrophilic PEG chains onto various material surfaces to improve biocompatibility and reduce non-specific binding.
• Prodrug Synthesis: Facilitates the design and synthesis of prodrugs with enhanced solubility and pharmacokinetic properties.
• Chemical Probe Development: A valuable tool for creating labeled compounds and probes for biochemical and diagnostic applications.

Basic Information

Product Name	Methyl-Peg3-Ms
CAS No.	74654-05-0
Molecular Formula	C9H20O6S
Molecular Weight	256.32 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-yl methanesulfonate; mPEG3-Ms; Methoxy-PEG3-mesylate; 1-Methoxy-2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethane mesylate; Methyl-triethylene glycol mesylate; PEG3 methyl ether mesylate; mPEG3-OMs; (2-{2-[2-(2-Methoxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate)
EINECS	Contact for details

Quality Control

Our Methyl-Peg3-Ms is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.