Description

3,4-Dihydro Ivermectin is a key intermediate in the synthesis of the broad-spectrum antiparasitic agent, Ivermectin. This compound is essential for pharmaceutical manufacturers requiring high-purity building blocks for the production of active pharmaceutical ingredients (APIs). It is primarily utilized by the pharmaceutical and veterinary medicine industries for the development and manufacturing of endoparasiticidal treatments.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of Ivermectin B1a and related macrocyclic lactone APIs.
• Veterinary Drug Manufacturing: Used in the production of formulations for treating parasitic infections in livestock and companion animals.
• Research & Development: Serves as a standard or starting material in medicinal chemistry research for novel antiparasitic agents.
• Process Chemistry: Employed in scale-up and optimization studies for commercial Ivermectin production processes.
• Reference Standard: Can be utilized as an analytical reference standard for quality control and regulatory testing.

Basic Information

Product Name	3,4-Dihydro Ivermectin
CAS No.	74567-01-4
Molecular Formula	C₄₈H₇₄O₁₄
Molecular Weight	875.1 g/mol
Synonyms	22,23-Dihydroavermectin B1a; 22,23-Dihydroivermectin B1a; Ivermectin B1a Dihydro Derivative; 5-O-Demethyl-22,23-dihydroavermectin A1a; (10E,14E,16E)-(1R,4S,5'S,6R,6'R,8R,12S,13S,20R,21R,24S)-6'-[(S)-sec-Butyl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxo-3,7,19-trioxatetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosa-10,14,16,22-tetraene-6-spiro-2'-(5',6'-dihydro-2'H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside
EINECS	Contact for details

Quality Control

Our 3,4-Dihydro Ivermectin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting purity, related substances, and residual solvents are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.