Description

5-[(4-Fluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid is a high-purity, synthetically valuable organic building block featuring a thiophene core functionalized with a carboxylic acid and a fluorinated phenoxymethyl group. This compound matters as a critical intermediate for advanced research and development in medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical synthesis companies seeking to incorporate its unique fluorinated heterocyclic scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in therapeutic areas targeting inflammation, CNS disorders, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated thiophene moiety.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Utilized in organometallic chemistry for creating complex ligands used in catalysis and sensor development.
• Chemical Biology Probe: Acts as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	5-[(4-Fluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid
CAS No.	74556-80-2
Molecular Formula	C12H9FO3S
Molecular Weight	252.26 g/mol
Synonyms	2-Thiophenecarboxylic acid, 5-[(4-fluorophenoxy)methyl]-; 5-[(4-Fluorophenoxy)methyl]-2-thiophenecarboxylic acid; 5-[(p-Fluorophenoxy)methyl]thiophene-2-carboxylic acid; 4-Fluorophenoxymethyl thiophene-2-carboxylic acid; 5-(4-Fluorophenoxymethyl)thiophene-2-carboxylic acid; 74556-80-2; Thiophene-2-carboxylic acid derivative with 4-fluorophenoxymethyl substituent
EINECS	Contact for details

Quality Control

Our 5-[(4-Fluorophenoxy)Methyl]Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.