Description

n-(6-Bromo-4-Hydroxyquinazolin-2-Yl)Guanidine is a high-purity, advanced pharmaceutical intermediate with a distinct quinazoline-guanidine hybrid structure. This compound matters for its critical role as a key building block in the synthesis of targeted kinase inhibitors and other bioactive molecules. Pharmaceutical R&D and fine chemical manufacturers need it for developing new therapeutic agents, particularly in oncology and signal transduction research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard and a core scaffold in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic compounds due to its reactive bromo and guanidine functional groups.
• API Development: Serves as a critical intermediate in the development and scale-up of Active Pharmaceutical Ingredients (APIs) with specific biological targets.

Basic Information

Product Name	n-(6-Bromo-4-Hydroxyquinazolin-2-Yl)Guanidine
CAS No.	74189-10-9
Molecular Formula	C9H8BrN5O
Molecular Weight	282.10 g/mol
Synonyms	2-Guanidino-6-bromo-4(3H)-quinazolinone; 6-Bromo-2-(guanidino)-4(3H)-quinazolinone; 6-Bromo-4-hydroxy-2-guanidinoquinazoline; Guanidine, N-(6-bromo-4-hydroxy-2-quinazolinyl)-; 74189-10-9; 6-Bromo-4-hydroxyquinazolin-2-ylguanidine; 2-(Diaminomethylideneamino)-6-bromo-3H-quinazolin-4-one
EINECS	Contact for details

Quality Control

Our n-(6-Bromo-4-Hydroxyquinazolin-2-Yl)Guanidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.