Description

Quinazoline, 4-Chloro-2-Methyl-6-Nitro- is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of quinazoline-based drug candidates targeting kinases, with potential applications in oncology and anti-inflammatory therapies.
• Agrochemical Synthesis: Serves as a core scaffold for developing new herbicides, fungicides, and insecticides, leveraging its bioactive quinazoline structure.
• Material Science Research: Used in the development of organic electronic materials, such as charge-transport layers or luminescent compounds, due to its electron-deficient aromatic system.
• Dye & Pigment Intermediate: Acts as a building block for synthesizing specialized heterocyclic dyes and pigments, where the nitro and chloro groups offer sites for further functionalization.
• Academic & Contract Research: Employed in university and CRO laboratories for method development, library synthesis, and exploring new chemical reactions involving halogenated nitroarenes.
• Custom Synthesis & Scale-Up: A vital starting material for custom manufacturing organizations (CMOs) producing kilogram to multi-kilogram quantities for client projects.

Basic Information

Product Name	Quinazoline, 4-Chloro-2-Methyl-6-Nitro-
CAS No.	74151-22-7
Molecular Formula	C9H6ClN3O2
Molecular Weight	223.62 g/mol
Synonyms	4-Chloro-2-methyl-6-nitroquinazoline; 6-Nitro-4-chloro-2-methylquinazoline; 2-Methyl-4-chloro-6-nitroquinazoline; 4-Chloro-6-nitro-2-methylquinazoline; Quinazoline, 4-chloro-2-methyl-6-nitro-; 74151-22-7; 4-Chloro-2-methyl-6-nitro-quinazoline
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Methyl-6-Nitroquinazoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity to be easily oxidized, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.