Description

3-[(2,2,2-Trifluoroethyl)Carbamoyl]-7-Oxabicyclo[2.2.1]Heptane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique bicyclic oxanorbornane scaffold modified with a trifluoroethyl carboxamide moiety. This compound is valued for its structural complexity and functional groups, which make it a critical building block in modern medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and metabolic diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: The oxabicyclo[2.2.1]heptane core is a known scaffold for designing inhibitors of various enzymes, including proteases.
• Agrochemical Synthesis: Potential intermediate for creating novel herbicides or fungicides that leverage the stability and bioactivity of the fluorinated bicyclic structure.
• Material Science Precursor: Can be utilized in the synthesis of specialized monomers or ligands for advanced polymers and catalysts.

Basic Information

Product Name	3-[(2,2,2-Trifluoroethyl)Carbamoyl]-7-Oxabicyclo[2.2.1]Heptane-2-Carboxylic Acid
CAS No.	73806-06-1
Molecular Formula	C11H12F3NO4
Molecular Weight	279.21 g/mol
Synonyms	7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[[(2,2,2-trifluoroethyl)amino]carbonyl]-; 3-(2,2,2-Trifluoroethylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid; 2-Norbornanecarboxylic acid, 3-[[(2,2,2-trifluoroethyl)amino]carbonyl]-, 1,7-didehydro-; 3-[(2,2,2-Trifluoroethyl)aminocarbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid; 73806-06-1; 3-(Trifluoroethylcarbamoyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-[(2,2,2-Trifluoroethyl)Carbamoyl]-7-Oxabicyclo[2.2.1]Heptane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurity profile, and other critical parameters are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.