Description

2-(Chlorodifluoromethyl)-4-Nitro-6-(Trifluoromethyl)-1H-Benzimidazole-1-Carboxylic Acid Ethyl Ester is a high-value, multi-functional benzimidazole derivative characterized by its unique trifluoromethyl and chlorodifluoromethyl substituents. This compound serves as a critical advanced intermediate in the synthesis of complex molecules, offering significant value in the development of novel active ingredients. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel benzimidazole-based active pharmaceutical ingredients (APIs), particularly for antiviral, antifungal, or anticancer applications.
• Agrochemical Intermediate: Used in the development of next-generation fungicides, herbicides, and insecticides, where the fluorine-containing groups can improve metabolic stability and bioavailability.
• Material Science Research: Investigated as a precursor for specialty polymers, liquid crystals, or organic electronic materials due to its rigid, fluorinated aromatic structure.
• Chemical Synthesis: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	2-(Chlorodifluoromethyl)-4-Nitro-6-(Trifluoromethyl)-1H-Benzimidazole-1-Carboxylic Acid Ethyl Ester
CAS No.	73618-60-7
Molecular Formula	C12H7ClF5N3O4
Molecular Weight	387.65 g/mol
Synonyms	Ethyl 2-(chlorodifluoromethyl)-4-nitro-6-(trifluoromethyl)-1H-benzimidazole-1-carboxylate; 1H-Benzimidazole-1-carboxylic acid, 2-(chlorodifluoromethyl)-4-nitro-6-(trifluoromethyl)-, ethyl ester; 73618-60-7; 2-(Chlorodifluoromethyl)-4-nitro-6-(trifluoromethyl)benzimidazole-1-carboxylic acid ethyl ester; Ethyl 2-(chlorodifluoromethyl)-4-nitro-6-(trifluoromethyl)benzimidazole-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of our 2-(Chlorodifluoromethyl)-4-Nitro-6-(Trifluoromethyl)-1H-Benzimidazole-1-Carboxylic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.