Description

Hyaluronate Hexasaccharide CAS NO 73603-40-4 is a defined, low molecular weight oligosaccharide fragment derived from the enzymatic or chemical depolymerization of high molecular weight hyaluronic acid (HA). This specific hexamer is valued for its enhanced bioavailability and targeted biological activity compared to its polymeric counterpart. It serves as a critical raw material and research standard for advanced applications in the pharmaceutical, cosmetic, and nutraceutical industries, where precise molecular structure and purity are paramount.

Application

• Pharmaceutical R&D & Formulation: Used as a key intermediate in the development of novel therapeutics targeting inflammation, wound healing, and osteoarthritis, leveraging its specific receptor-binding properties.
• Advanced Cosmetic Actives: Incorporated into high-performance serums, creams, and dermal fillers for its superior skin penetration and ability to stimulate collagen production and cellular regeneration.
• Biomedical Research: Serves as a standard and tool compound for studying HA-receptor interactions (e.g., CD44, RHAMM), cell signaling pathways, and angiogenesis in vitro and in vivo.
• Nutraceutical Ingredients: Formulated into dietary supplements aimed at supporting joint health, skin hydration, and anti-aging from within, due to its absorbable size.
• Drug Delivery Systems: Explored as a biocompatible carrier or targeting moiety for conjugating and delivering small molecule drugs, peptides, or nucleic acids to specific tissues.
• Cell Culture & Tissue Engineering: Used to functionalize scaffolds and hydrogels to create biomimetic environments that direct stem cell differentiation and tissue regeneration.

Basic Information

Product Name	Hyaluronate Hexasaccharide
CAS No.	73603-40-4
Molecular Formula	C72H111N5O55
Molecular Weight	~1890.6 g/mol
Synonyms	Hyaluronic Acid Hexasaccharide; HA Hexamer; Sodium Hyaluronate Hexasaccharide; Hyaluronan Hexasaccharide; (→4)-β-D-GlcA-(1→3)-β-D-GlcNAc-(1→4)-β-D-GlcA-(1→3)-β-D-GlcNAc-(1→4)-β-D-GlcA-(1→3)-D-GlcNAc; Hexasaccharide HA; Oligo-Hyaluronic Acid (6-mer); Low Molecular Weight Hyaluronic Acid Fragment
EINECS	Contact for details

Quality Control

Our Hyaluronate Hexasaccharide is produced and controlled under strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm molecular identity, chain length uniformity, and high purity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support compliance requirements for cGMP, ISO, and other relevant pharmaceutical and cosmetic ingredient standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0% (as Hyaluronate Hexasaccharide)
Molecular Weight Distribution	≥ 90% within target hexamer range (by SEC-MALS or HPLC)
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins (LAL)	< 0.5 EU/mg (for injectable grades)
Microbial Enumeration	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.